hydrogen rich saline

We herein aim to verify its protective effects in experimental models of liver injury. As an antioxidant hydrogen-rich water has been widely studied in recent years.

Different Effects Of Hydrogen Rich Water Intake And Hydrogen Gas Inhalation On Gut Microbiome And Plasma Metabolites Of Rats In Health Status Scientific Reports

Hydrogen-Rich Saline Regulates Microglial Phagocytosis and Restores Behavioral Deficits Following Hypoxia-Ischemia Injury in Neonatal Mice via the Akt Pathway.

. 1618 Previous studies have demonstrated that H2 dissolved in saline to generate a hydrogen-rich saline HRS solution. H2 concentration in vivo was detected by hydrogen microelectrode for the first time. We designed this study to investigate whether hydrogen-rich saline treatment could improve survival and neurological outcome after cardiac arrest and cardiopulmonary.

In addition the inflammation response and apoptosis were. Testicular torsion was performed by rotating the left testis 720 degrees clockwise for 4 hours. A 2-6-4-hydroxy phenoxy-3H-xanthen-3-on-9-yl benzoate HPF probe was used to detect intracellular hydroxyl radicals OH.

To ensure a concentration of 06 mmoll it was necessary to freshly prepare the hydrogen-rich saline. The saline-treated groups received hydrogen-rich saline 06 mM 6 mLkg or normal saline 6 mLkg respectively via the tail vein at the beginning of reperfusion. Hydrogen was dissolved in physiological saline for 6 h under high pressure 04 MPa to a supersaturated level using a hydrogen-rich water-producing apparatus produced by our department.

Then the saturated HRS was refrigerated at 4C and sterilized by γ radiation. 15 Soon afterward hydrogen therapy quickly gained attention in the fields of inflammation and allergy. Hydrogen-rich saline production.

Hydrogen was dissolved in normal saline under pressure at 05 MPa for 7 h to reach saturation by using an appropriate apparatus Nanobubble Technology Co Shanghai China. Hydrogen was dissolved in physiological saline for 4 h under 04 MPa pressure to a saturated level using a self-designed hydrogen-rich water-producing apparatus which was stored under atmospheric pressure at 4C in an aluminum bag with no dead volume. A Myocardial IR in vivo or HR-induced injury in H9C2 cells in vitro led to autophagy and mitophagy activation as evidenced by an increase in the expression of autophagy-associated proteins.

In 2007 Ohta et al found that hydrogen H2 had a selective antioxidant effect as well as an effective anti-inflammatory and anti-allergic effect. The saturated hydrogen saline was stored under atmospheric pressure at 4C in an aluminum bag with no dead volume. The two kinds of saline are only administered to the recipients at the time of graft reperfusion and not used in the preservation solution of the pancreas during the retrieval and cold ischemia.

Hydrogen-rich saline alleviates the inflammation response and apoptosis via PINK1Parkin-mediated mitophagy. Additionally hydrogen-rich saline markedly increased the activities of anti-oxidant enzymes superoxide dismutase and catalase and downregulated extracellular signal-regulated protein kinase ERK12 activation. We have reported previously that hydrogen-rich saline HS plays a neuroprotective role in hypoxia-ischemia HI brain damage in newborn mice.

The concentration of HRS was 06 mmolL as measured by gas chromatography. H2 was dissolved in physiological saline or medium using an apparatus produced by our department. In addition we detected the expressions of the BaxBcl-2 cleaved C8 and cleaved C3 in three groups and the western.

Hydrogen-rich saline reduced levels of these markers and relieved morphological liver injury. Liver damage ROS accumulation cytokine levels and apoptotic protein expression were respectively. Hydrogen-rich saline a portable easily administered and safe means of delivering hydrogen gas can exert organ-protective effects through regulating oxidative stress inflammation and apoptosis.

We investigated the effects of hydrogen-rich saline on doxorubicin-induced cell apoptosis. Numerous studies in biology and medicine show that hydrogen-rich water has achieved good results in nervous. It is mild enough neither to disturb metabolic redox reactions nor to affect signaling reactive oxygen species.

Centration of hydrogen in the air is greater than 4. Therefore there should be no or few adverse effects of H2. Male Sprague-Dawley rats were divided randomly into 4 groups including group 1-sham operated group 2-torsion-detorsion group 3-torsion-detorsion plus saline and group 4-torsion-detorsion plus hydrogen rich saline solution.

The TUNEL finding showed that hydrogen-rich saline treatment significantly ameliorated cell apoptosis in both cardiac and hepatic tissues. In place of H2 gas hydrogen-rich saline HS may be more suitable for clinical application. Hydrogen can be dissolved in water up to 08 mM under atmospheric pres - sure at room temperature and its solubilized form the hydro-gen-rich saline HRS is advantageous since it is a safe porta - ble and easily handled approach for delivery.

Cell apoptosis was evaluated by annexin V-FITC and Propidium iodide PI staining as well as the caspase 3 activity.

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